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Sabatini Lab Website Publications

An evolutionary mechanism to assimilate new nutrient sensors into the mTORC1 pathway.

Liu GY, Jouandin P, Bahng RE, Perrimon N, Sabatini DM.

bioRxiv. 2023 May 26:2023.05.25.541239. doi: 10.1101/2023.05.25.541239. Preprint.

PMID: 37292894

Collateral deletion of the mitochondrial AAA+ ATPase ATAD1 sensitizes cancer cells to proteasome dysfunction.

Winter JM, Fresenius HL, Cunningham CN, Wei P, Keys HR, Berg J, Bott A, Yadav T, Ryan J, Sirohi D, Tripp SR, Barta P, Agarwal N, Letai A, Sabatini DM, Wohlever ML, Rutter J.

Elife. 2022 Nov 21;11:e82860. doi: 10.7554/eLife.82860.

PMID: 36409067

CLN3 is required for the clearance of glycerophosphodiesters from lysosomes.

Laqtom NN, Dong W, Medoh UN, Cangelosi AL, Dharamdasani V, Chan SH, Kunchok T, Lewis CA, Heinze I, Tang R, Grimm C, Dang Do AN, Porter FD, Ori A, Sabatini DM, Abu-Remaileh M.

Nature. 2022 Sep;609(7929):1005-1011. doi: 10.1038/s41586-022-05221-y. Epub 2022 Sep 21.

PMID: 36131016

Sestrin mediates detection of and adaptation to low-leucine diets in Drosophila.

Gu X, Jouandin P, Lalgudi PV, Binari R, Valenstein ML, Reid MA, Allen AE, Kamitaki N, Locasale JW, Perrimon N, Sabatini DM.

Nature. 2022 Aug;608(7921):209-216. doi: 10.1038/s41586-022-04960-2. Epub 2022 Jul 20.

PMID: 35859173

Structure of the nutrient-sensing hub GATOR2.

Valenstein ML, Rogala KB, Lalgudi PV, Brignole EJ, Gu X, Saxton RA, Chantranupong L, Kolibius J, Quast JP, Sabatini DM.

Nature. 2022 Jul;607(7919):610-616. doi: 10.1038/s41586-022-04939-z. Epub 2022 Jul 13.

PMID: 35831510

Zonated leucine sensing by Sestrin-mTORC1 in the liver controls the response to dietary leucine.

Cangelosi AL, Puszynska AM, Roberts JM, Armani A, Nguyen TP, Spinelli JB, Kunchok T, Wang B, Chan SH, Lewis CA, Comb WC, Bell GW, Helman A, Sabatini DM.

Science. 2022 Jul;377(6601):47-56. doi: 10.1126/science.abi9547. Epub 2022 Jun 30.

PMID: 35771919

Fumarate is a terminal electron acceptor in the mammalian electron transport chain.

Spinelli JB, Rosen PC, Sprenger HG, Puszynska AM, Mann JL, Roessler JM, Cangelosi AL, Henne A, Condon KJ, Zhang T, Kunchok T, Lewis CA, Chandel NS, Sabatini DM.

Science. 2021 Dec 3;374(6572):1227-1237. doi: 10.1126/science.abi7495. Epub 2021 Dec 2.

PMID: 34855504

GCN2 adapts protein synthesis to scavenging-dependent growth.

Nofal M, Wang T, Yang L, Jankowski CSR, Hsin-Jung Li S, Han S, Parsons L, Frese AN, Gitai Z, Anthony TG, Wühr M, Sabatini DM, Rabinowitz JD.

Cell Syst. 2022 Feb 16;13(2):158-172.e9. doi: 10.1016/j.cels.2021.09.014. Epub 2021 Oct 26.

PMID: 34706266

Limited survival and impaired hepatic fasting metabolism in mice with constitutive Rag GTPase signaling.

de la Calle Arregui C, Plata-Gómez AB, Deleyto-Seldas N, García F, Ortega-Molina A, Abril-Garrido J, Rodriguez E, Nemazanyy I, Tribouillard L, de Martino A, Caleiras E, Campos-Olivas R, Mulero F, Laplante M, Muñoz J, Pende M, Sabio G, Sabatini DM, Efeyan A.

Nat Commun. 2021 Jun 16;12(1):3660. doi: 10.1038/s41467-021-23857-8.

PMID: 34135321

APOE4 disrupts intracellular lipid homeostasis in human iPSC-derived glia.

Sienski G, Narayan P, Bonner JM, Kory N, Boland S, Arczewska AA, Ralvenius WT, Akay L, Lockshin E, He L, Milo B, Graziosi A, Baru V, Lewis CA, Kellis M, Sabatini DM, Tsai LH, Lindquist S.

Sci Transl Med. 2021 Mar 3;13(583):eaaz4564. doi: 10.1126/scitranslmed.aaz4564.

PMID: 33658354

CRISPR screens in physiologic medium reveal conditionally essential genes in human cells.

Rossiter NJ, Huggler KS, Adelmann CH, Keys HR, Soens RW, Sabatini DM, Cantor JR.

Cell Metab. 2021 Jun 1;33(6):1248-1263.e9. doi: 10.1016/j.cmet.2021.02.005. Epub 2021 Mar 1.

PMID: 33651980

Genome-wide CRISPR screens reveal multitiered mechanisms through which mTORC1 senses mitochondrial dysfunction.

Condon KJ, Orozco JM, Adelmann CH, Spinelli JB, van der Helm PW, Roberts JM, Kunchok T, Sabatini DM.

Proc Natl Acad Sci U S A. 2021 Jan 26;118(4):e2022120118. doi: 10.1073/pnas.2022120118.

PMID: 33483422

MFSD12 mediates the import of cysteine into melanosomes and lysosomes.

Adelmann CH, Traunbauer AK, Chen B, Condon KJ, Chan SH, Kunchok T, Lewis CA, Sabatini DM.

Nature. 2020 Dec;588(7839):699-704. doi: 10.1038/s41586-020-2937-x. Epub 2020 Nov 18.

PMID: 33208952

Metabolic determinants of cellular fitness dependent on mitochondrial reactive oxygen species.

Kong H, Reczek CR, McElroy GS, Steinert EM, Wang T, Sabatini DM, Chandel NS.

Sci Adv. 2020 Nov 4;6(45):eabb7272. doi: 10.1126/sciadv.abb7272. Print 2020 Nov.

PMID: 33148642

MCART1/SLC25A51 is required for mitochondrial NAD transport.

Kory N, Uit de Bos J, van der Rijt S, Jankovic N, Güra M, Arp N, Pena IA, Prakash G, Chan SH, Kunchok T, Lewis CA, Sabatini DM.

Sci Adv. 2020 Oct 21;6(43):eabe5310. doi: 10.1126/sciadv.abe5310. Print 2020 Oct.

PMID: 33087354

Dihydroxyacetone phosphate signals glucose availability to mTORC1.

Orozco JM, Krawczyk PA, Scaria SM, Cangelosi AL, Chan SH, Kunchok T, Lewis CA, Sabatini DM.

Nat Metab. 2020 Sep;2(9):893-901. doi: 10.1038/s42255-020-0250-5. Epub 2020 Jul 27.

PMID: 32719541

Increased lysosomal biomass is responsible for the resistance of triple-negative breast cancers to CDK4/6 inhibition.

Fassl A, Brain C, Abu-Remaileh M, Stukan I, Butter D, Stepien P, Feit AS, Bergholz J, Michowski W, Otto T, Sheng Q, Loo A, Michael W, Tiedt R, DeAngelis C, Schiff R, Jiang B, Jovanovic B, Nowak K, Ericsson M, Cameron M, Gray N, Dillon D, Zhao JJ, Sabatini DM, Jeselsohn R, Brown M, Polyak K, Sicinski P.

Sci Adv. 2020 Jun 17;6(25):eabb2210. doi: 10.1126/sciadv.abb2210. eCollection 2020 Jun.

PMID: 32704543

Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition.

Ngo B, Kim E, Osorio-Vasquez V, Doll S, Bustraan S, Liang RJ, Luengo A, Davidson SM, Ali A, Ferraro GB, Fischer GM, Eskandari R, Kang DS, Ni J, Plasger A, Rajasekhar VK, Kastenhuber ER, Bacha S, Sriram RK, Stein BD, Bakhoum SF, Snuderl M, Cotzia P, Healey JH, Mainolfi N, Suri V, Friedman A, Manfredi M, Sabatini DM, Jones DR, Yu M, Zhao JJ, Jain RK, Keshari KR, Davies MA, Vander Heiden MG, Hernando E, Mann M, Cantley LC, Pacold ME.

Cancer Discov. 2020 Sep;10(9):1352-1373. doi: 10.1158/2159-8290.CD-19-1228. Epub 2020 Jun 22.

PMID: 32571778

ATRAID regulates the action of nitrogen-containing bisphosphonates on bone.

Surface LE, Burrow DT, Li J, Park J, Kumar S, Lyu C, Song N, Yu Z, Rajagopal A, Bae Y, Lee BH, Mumm S, Gu CC, Baker JC, Mohseni M, Sum M, Huskey M, Duan S, Bijanki VN, Civitelli R, Gardner MJ, McAndrew CM, Ricci WM, Gurnett CA, Diemer K, Wan F, Costantino CL, Shannon KM, Raje N, Dodson TB, Haber DA, Carette JE, Varadarajan M, Brummelkamp TR, Birsoy K, Sabatini DM, Haller G, Peterson TR.

Sci Transl Med. 2020 May 20;12(544):eaav9166. doi: 10.1126/scitranslmed.aav9166.

PMID: 32434850

A PEROXO-Tag Enables Rapid Isolation of Peroxisomes from Human Cells.

Ray GJ, Boydston EA, Shortt E, Wyant GA, Lourido S, Chen WW, Sabatini DM.

iScience. 2020 May 22;23(5):101109. doi: 10.1016/j.isci.2020.101109. Epub 2020 Apr 28.

PMID: 32417403

A Nutrient-Sensing Transition at Birth Triggers Glucose-Responsive Insulin Secretion.

Helman A, Cangelosi AL, Davis JC, Pham Q, Rothman A, Faust AL, Straubhaar JR, Sabatini DM, Melton DA.

Cell Metab. 2020 May 5;31(5):1004-1016.e5. doi: 10.1016/j.cmet.2020.04.004.

PMID: 32375022

Dietary modifications for enhanced cancer therapy.

Kanarek N, Petrova B, Sabatini DM.

Nature. 2020 Mar;579(7800):507-517. doi: 10.1038/s41586-020-2124-0. Epub 2020 Mar 25.

PMID: 32214253

A human ciliopathy reveals essential functions for NEK10 in airway mucociliary clearance.

Chivukula RR, Montoro DT, Leung HM, Yang J, Shamseldin HE, Taylor MS, Dougherty GW, Zariwala MA, Carson J, Daniels MLA, Sears PR, Black KE, Hariri LP, Almogarri I, Frenkel EM, Vinarsky V, Omran H, Knowles MR, Tearney GJ, Alkuraya FS, Sabatini DM.

Nat Med. 2020 Feb;26(2):244-251. doi: 10.1038/s41591-019-0730-x. Epub 2020 Jan 20.

PMID: 31959991

mTOR at the nexus of nutrition, growth, ageing and disease.

Liu GY, Sabatini DM.

Nat Rev Mol Cell Biol. 2020 Apr;21(4):183-203. doi: 10.1038/s41580-019-0199-y. Epub 2020 Jan 14.

PMID: 31937935

Nutrient regulation of mTORC1 at a glance.

Condon KJ, Sabatini DM.

J Cell Sci. 2019 Nov 13;132(21):jcs222570. doi: 10.1242/jcs.222570.

PMID: 31722960

Cryo-EM Structure of the Human FLCN-FNIP2-Rag-Ragulator Complex.

Shen K, Rogala KB, Chou HT, Huang RK, Yu Z, Sabatini DM.

Cell. 2019 Nov 27;179(6):1319-1329.e8. doi: 10.1016/j.cell.2019.10.036. Epub 2019 Nov 6.

PMID: 31704029

Nutrient mTORC1 signaling underpins regulatory T cell control of immune tolerance.

Do MH, Wang X, Zhang X, Chou C, Nixon BG, Capistrano KJ, Peng M, Efeyan A, Sabatini DM, Li MO.

J Exp Med. 2020 Jan 6;217(1):e20190848. doi: 10.1084/jem.20190848.

PMID: 31649036

Architecture of human Rag GTPase heterodimers and their complex with mTORC1.

Anandapadamanaban M, Masson GR, Perisic O, Berndt A, Kaufman J, Johnson CM, Santhanam B, Rogala KB, Sabatini DM, Williams RL.

Science. 2019 Oct 11;366(6462):203-210. doi: 10.1126/science.aax3939.

PMID: 31601764

Structural basis for the docking of mTORC1 on the lysosomal surface.

Rogala KB, Gu X, Kedir JF, Abu-Remaileh M, Bianchi LF, Bottino AMS, Dueholm R, Niehaus A, Overwijn D, Fils AP, Zhou SX, Leary D, Laqtom NN, Brignole EJ, Sabatini DM.

Science. 2019 Oct 25;366(6464):468-475. doi: 10.1126/science.aay0166. Epub 2019 Oct 10.

PMID: 31601708

C7orf59/LAMTOR4 phosphorylation and structural flexibility modulate Ragulator assembly.

Rasheed N, Lima TB, Mercaldi GF, Nascimento AFZ, Silva ALS, Righetto GL, Bar-Peled L, Shen K, Sabatini DM, Gozzo FC, Aparicio R, Smetana JHC.

FEBS Open Bio. 2019 Sep;9(9):1589-1602. doi: 10.1002/2211-5463.12700. Epub 2019 Jul 28.

PMID: 31314152

Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium.

Pentinmikko N, Iqbal S, Mana M, Andersson S, Cognetta AB 3rd, Suciu RM, Roper J, Luopajärvi K, Markelin E, Gopalakrishnan S, Smolander OP, Naranjo S, Saarinen T, Juuti A, Pietiläinen K, Auvinen P, Ristimäki A, Gupta N, Tammela T, Jacks T, Sabatini DM, Cravatt BF, Yilmaz ÖH, Katajisto P.

Nature. 2019 Jul;571(7765):398-402. doi: 10.1038/s41586-019-1383-0. Epub 2019 Jul 10.

PMID: 31292548

Activation of PASK by mTORC1 is required for the onset of the terminal differentiation program.

Kikani CK, Wu X, Fogarty S, Kang SAW, Dephoure N, Gygi SP, Sabatini DM, Rutter J.

Proc Natl Acad Sci U S A. 2019 May 21;116(21):10382-10391. doi: 10.1073/pnas.1804013116. Epub 2019 May 9.

PMID: 31072927

Genome-wide CRISPR screen for Zika virus resistance in human neural cells.

Li Y, Muffat J, Omer Javed A, Keys HR, Lungjangwa T, Bosch I, Khan M, Virgilio MC, Gehrke L, Sabatini DM, Jaenisch R.

Proc Natl Acad Sci U S A. 2019 May 7;116(19):9527-9532. doi: 10.1073/pnas.1900867116. Epub 2019 Apr 24.

PMID: 31019072

Squalene accumulation in cholesterol auxotrophic lymphomas prevents oxidative cell death.

Garcia-Bermudez J, Baudrier L, Bayraktar EC, Shen Y, La K, Guarecuco R, Yucel B, Fiore D, Tavora B, Freinkman E, Chan SH, Lewis C, Min W, Inghirami G, Sabatini DM, Birsoy K.

Nature. 2019 Mar;567(7746):118-122. doi: 10.1038/s41586-019-0945-5. Epub 2019 Feb 13.

PMID: 30760928

Arg-78 of Nprl2 catalyzes GATOR1-stimulated GTP hydrolysis by the Rag GTPases.

Shen K, Valenstein ML, Gu X, Sabatini DM.

J Biol Chem. 2019 Feb 22;294(8):2970-2975. doi: 10.1074/jbc.AC119.007382. Epub 2019 Jan 16.

PMID: 30651352

The next decade of metabolism.

Bäckhed F, Bugianesi E, Christofk H, Dikic I, Gupta R, Mair WB, O'Neill LAJ, Ralser M, Sabatini DM, Tschöp M.

Nat Metab. 2019 Jan;1(1):2-4. doi: 10.1038/s42255-018-0022-7.

PMID: 32694817

Genome-Wide CRISPR/Cas9 Screening for Identification of Cancer Genes in Cell Lines.

Adelmann CH, Wang T, Sabatini DM, Lander ES.

Methods Mol Biol. 2019;1907:125-136. doi: 10.1007/978-1-4939-8967-6_10.

PMID: 30542996

MITO-Tag Mice enable rapid isolation and multimodal profiling of mitochondria from specific cell types in vivo.

Bayraktar EC, Baudrier L, Özerdem C, Lewis CA, Chan SH, Kunchok T, Abu-Remaileh M, Cangelosi AL, Sabatini DM, Birsoy K, Chen WW.

Proc Natl Acad Sci U S A. 2019 Jan 2;116(1):303-312. doi: 10.1073/pnas.1816656115. Epub 2018 Dec 12.

PMID: 30541894

SFXN1 is a mitochondrial serine transporter required for one-carbon metabolism.

Kory N, Wyant GA, Prakash G, Uit de Bos J, Bottanelli F, Pacold ME, Chan SH, Lewis CA, Wang T, Keys HR, Guo YE, Sabatini DM.

Science. 2018 Nov 16;362(6416):eaat9528. doi: 10.1126/science.aat9528.

PMID: 30442778

Ragulator and SLC38A9 activate the Rag GTPases through noncanonical GEF mechanisms.

Shen K, Sabatini DM.

Proc Natl Acad Sci U S A. 2018 Sep 18;115(38):9545-9550. doi: 10.1073/pnas.1811727115. Epub 2018 Sep 4.

PMID: 30181260

Histidine catabolism is a major determinant of methotrexate sensitivity.

Kanarek N, Keys HR, Cantor JR, Lewis CA, Chan SH, Kunchok T, Abu-Remaileh M, Freinkman E, Schweitzer LD, Sabatini DM.

Nature. 2018 Jul;559(7715):632-636. doi: 10.1038/s41586-018-0316-7. Epub 2018 Jul 11.

PMID: 29995852

DEPTOR modulates activation responses in CD4+ T cells and enhances immunoregulation following transplantation.

Wedel J, Bruneau S, Liu K, Kong SW, Sage PT, Sabatini DM, Laplante M, Briscoe DM.

Am J Transplant. 2019 Jan;19(1):77-88. doi: 10.1111/ajt.14995. Epub 2018 Aug 17.

PMID: 29969188

Identification of a transporter complex responsible for the cytosolic entry of nitrogen-containing bisphosphonates.

Yu Z, Surface LE, Park CY, Horlbeck MA, Wyant GA, Abu-Remaileh M, Peterson TR, Sabatini DM, Weissman JS, O'Shea EK.

Elife. 2018 May 10;7:e36620. doi: 10.7554/eLife.36620.

PMID: 29745899

Fasting Activates Fatty Acid Oxidation to Enhance Intestinal Stem Cell Function during Homeostasis and Aging.

Mihaylova MM, Cheng CW, Cao AQ, Tripathi S, Mana MD, Bauer-Rowe KE, Abu-Remaileh M, Clavain L, Erdemir A, Lewis CA, Freinkman E, Dickey AS, La Spada AR, Huang Y, Bell GW, Deshpande V, Carmeliet P, Katajisto P, Sabatini DM, Yilmaz ÖH.

Cell Stem Cell. 2018 May 3;22(5):769-778.e4. doi: 10.1016/j.stem.2018.04.001.

PMID: 29727683

NUFIP1 is a ribosome receptor for starvation-induced ribophagy.

Wyant GA, Abu-Remaileh M, Frenkel EM, Laqtom NN, Dharamdasani V, Lewis CA, Chan SH, Heinze I, Ori A, Sabatini DM.

Science. 2018 May 18;360(6390):751-758. doi: 10.1126/science.aar2663. Epub 2018 Apr 26.

PMID: 29700228

Architecture of the human GATOR1 and GATOR1-Rag GTPases complexes.

Shen K, Huang RK, Brignole EJ, Condon KJ, Valenstein ML, Chantranupong L, Bomaliyamu A, Choe A, Hong C, Yu Z, Sabatini DM.

Nature. 2018 Apr 5;556(7699):64-69. doi: 10.1038/nature26158. Epub 2018 Mar 28.

PMID: 29590090

Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors.

Rohde JM, Brimacombe KR, Liu L, Pacold ME, Yasgar A, Cheff DM, Lee TD, Rai G, Baljinnyam B, Li Z, Simeonov A, Hall MD, Shen M, Sabatini DM, Boxer MB.

Bioorg Med Chem. 2018 May 1;26(8):1727-1739. doi: 10.1016/j.bmc.2018.02.016. Epub 2018 Feb 27.

PMID: 29555419

Rapid immunopurification of mitochondria for metabolite profiling and absolute quantification of matrix metabolites.

Chen WW, Freinkman E, Sabatini DM.

Nat Protoc. 2017 Oct;12(10):2215-2231. doi: 10.1038/nprot.2017.104. Epub 2017 Sep 29.

PMID: 29532801

Serine Catabolism by SHMT2 Is Required for Proper Mitochondrial Translation Initiation and Maintenance of Formylmethionyl-tRNAs.

Minton DR, Nam M, McLaughlin DJ, Shin J, Bayraktar EC, Alvarez SW, Sviderskiy VO, Papagiannakopoulos T, Sabatini DM, Birsoy K, Possemato R.

Mol Cell. 2018 Feb 15;69(4):610-621.e5. doi: 10.1016/j.molcel.2018.01.024.

PMID: 29452640

A mouse model of DEPDC5-related epilepsy: Neuronal loss of Depdc5 causes dysplastic and ectopic neurons, increased mTOR signaling, and seizure susceptibility.

Yuskaitis CJ, Jones BM, Wolfson RL, Super CE, Dhamne SC, Rotenberg A, Sabatini DM, Sahin M, Poduri A.

Neurobiol Dis. 2018 Mar;111:91-101. doi: 10.1016/j.nbd.2017.12.010. Epub 2017 Dec 20.

PMID: 29274432

NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis.

Alvarez SW, Sviderskiy VO, Terzi EM, Papagiannakopoulos T, Moreira AL, Adams S, Sabatini DM, Birsoy K, Possemato R.

Nature. 2017 Nov 30;551(7682):639-643. doi: 10.1038/nature24637. Epub 2017 Nov 22.

PMID: 29168506

Intersubunit Crosstalk in the Rag GTPase Heterodimer Enables mTORC1 to Respond Rapidly to Amino Acid Availability.

Shen K, Choe A, Sabatini DM.

Mol Cell. 2017 Nov 16;68(4):821. doi: 10.1016/j.molcel.2017.10.031.

PMID: 29149601

SAMTOR is an S-adenosylmethionine sensor for the mTORC1 pathway.

Gu X, Orozco JM, Saxton RA, Condon KJ, Liu GY, Krawczyk PA, Scaria SM, Harper JW, Gygi SP, Sabatini DM.

Science. 2017 Nov 10;358(6364):813-818. doi: 10.1126/science.aao3265.

PMID: 29123071

Twenty-five years of mTOR: Uncovering the link from nutrients to growth.

Sabatini DM.

Proc Natl Acad Sci U S A. 2017 Nov 7;114(45):11818-11825. doi: 10.1073/pnas.1716173114. Epub 2017 Oct 25.

PMID: 29078414

Lysosomal metabolomics reveals V-ATPase- and mTOR-dependent regulation of amino acid efflux from lysosomes.

Abu-Remaileh M, Wyant GA, Kim C, Laqtom NN, Abbasi M, Chan SH, Freinkman E, Sabatini DM.

Science. 2017 Nov 10;358(6364):807-813. doi: 10.1126/science.aan6298. Epub 2017 Oct 26.

PMID: 29074583

A CRISPR screen identifies a pathway required for paraquat-induced cell death.

Reczek CR, Birsoy K, Kong H, Martínez-Reyes I, Wang T, Gao P, Sabatini DM, Chandel NS.

Nat Chem Biol. 2017 Dec;13(12):1274-1279. doi: 10.1038/nchembio.2499. Epub 2017 Oct 23.

PMID: 29058724

mTORC1 Activator SLC38A9 Is Required to Efflux Essential Amino Acids from Lysosomes and Use Protein as a Nutrient.

Wyant GA, Abu-Remaileh M, Wolfson RL, Chen WW, Freinkman E, Danai LV, Vander Heiden MG, Sabatini DM.

Cell. 2017 Oct 19;171(3):642-654.e12. doi: 10.1016/j.cell.2017.09.046.

PMID: 29053970

The Dawn of the Age of Amino Acid Sensors for the mTORC1 Pathway.

Wolfson RL, Sabatini DM.

Cell Metab. 2017 Aug 1;26(2):301-309. doi: 10.1016/j.cmet.2017.07.001.

PMID: 28768171

Germinal Center Selection and Affinity Maturation Require Dynamic Regulation of mTORC1 Kinase.

Ersching J, Efeyan A, Mesin L, Jacobsen JT, Pasqual G, Grabiner BC, Dominguez-Sola D, Sabatini DM, Victora GD.

Immunity. 2017 Jun 20;46(6):1045-1058.e6. doi: 10.1016/j.immuni.2017.06.005.

PMID: 28636954

Loss of hepatic DEPTOR alters the metabolic transition to fasting.

Caron A, Mouchiroud M, Gautier N, Labbé SM, Villot R, Turcotte L, Secco B, Lamoureux G, Shum M, Gélinas Y, Marette A, Richard D, Sabatini DM, Laplante M.

Mol Metab. 2017 Feb 17;6(5):447-458. doi: 10.1016/j.molmet.2017.02.005. eCollection 2017 May.

PMID: 28462079

PIK3CA mutant tumors depend on oxoglutarate dehydrogenase.

Ilic N, Birsoy K, Aguirre AJ, Kory N, Pacold ME, Singh S, Moody SE, DeAngelo JD, Spardy NA, Freinkman E, Weir BA, Tsherniak A, Cowley GS, Root DE, Asara JM, Vazquez F, Widlund HR, Sabatini DM, Hahn WC.

Proc Natl Acad Sci U S A. 2017 Apr 25;114(17):E3434-E3443. doi: 10.1073/pnas.1617922114. Epub 2017 Apr 10.

PMID: 28396387

mTOR Signaling in Growth, Metabolism, and Disease.

Saxton RA, Sabatini DM.

Cell. 2017 Apr 6;169(2):361-371. doi: 10.1016/j.cell.2017.03.035.

PMID: 28388417

Physiologic Medium Rewires Cellular Metabolism and Reveals Uric Acid as an Endogenous Inhibitor of UMP Synthase.

Cantor JR, Abu-Remaileh M, Kanarek N, Freinkman E, Gao X, Louissaint A Jr, Lewis CA, Sabatini DM.

Cell. 2017 Apr 6;169(2):258-272.e17. doi: 10.1016/j.cell.2017.03.023.

PMID: 28388410

Amino acid-insensitive mTORC1 regulation enables nutritional stress resilience in hematopoietic stem cells.

Kalaitzidis D, Lee D, Efeyan A, Kfoury Y, Nayyar N, Sykes DB, Mercier FE, Papazian A, Baryawno N, Victora GD, Neuberg D, Sabatini DM, Scadden DT.

J Clin Invest. 2017 Apr 3;127(4):1405-1413. doi: 10.1172/JCI89452. Epub 2017 Mar 20.

PMID: 28319048

KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1.

Wolfson RL, Chantranupong L, Wyant GA, Gu X, Orozco JM, Shen K, Condon KJ, Petri S, Kedir J, Scaria SM, Abu-Remaileh M, Frankel WN, Sabatini DM.

Nature. 2017 Mar 16;543(7645):438-442. doi: 10.1038/nature21423. Epub 2017 Feb 15.

PMID: 28199306

Gene Essentiality Profiling Reveals Gene Networks and Synthetic Lethal Interactions with Oncogenic Ras.

Wang T, Yu H, Hughes NW, Liu B, Kendirli A, Klein K, Chen WW, Lander ES, Sabatini DM.

Cell. 2017 Feb 23;168(5):890-903.e15. doi: 10.1016/j.cell.2017.01.013. Epub 2017 Feb 2.

PMID: 28162770

A genome-wide CRISPR screen identifies a restricted set of HIV host dependency factors.

Park RJ, Wang T, Koundakjian D, Hultquist JF, Lamothe-Molina P, Monel B, Schumann K, Yu H, Krupzcak KM, Garcia-Beltran W, Piechocka-Trocha A, Krogan NJ, Marson A, Sabatini DM, Lander ES, Hacohen N, Walker BD.

Nat Genet. 2017 Feb;49(2):193-203. doi: 10.1038/ng.3741. Epub 2016 Dec 19.

PMID: 27992415

ERK and p38 MAPK Activities Determine Sensitivity to PI3K/mTOR Inhibition via Regulation of MYC and YAP.

Muranen T, Selfors LM, Hwang J, Gallegos LL, Coloff JL, Thoreen CC, Kang SA, Sabatini DM, Mills GB, Brugge JS.

Cancer Res. 2016 Dec 15;76(24):7168-7180. doi: 10.1158/0008-5472.CAN-16-0155. Epub 2016 Oct 20.

PMID: 27913436

The apo-structure of the leucine sensor Sestrin2 is still elusive.

Saxton RA, Knockenhauer KE, Schwartz TU, Sabatini DM.

Sci Signal. 2016 Sep 20;9(446):ra92. doi: 10.1126/scisignal.aah4497.

PMID: 27649739

Absolute Quantification of Matrix Metabolites Reveals the Dynamics of Mitochondrial Metabolism.

Chen WW, Freinkman E, Wang T, Birsoy K, Sabatini DM.

Cell. 2016 Aug 25;166(5):1324-1337.e11. doi: 10.1016/j.cell.2016.07.040.

PMID: 27565352

Mechanism of arginine sensing by CASTOR1 upstream of mTORC1.

Saxton RA, Chantranupong L, Knockenhauer KE, Schwartz TU, Sabatini DM.

Nature. 2016 Aug 11;536(7615):229-33. doi: 10.1038/nature19079. Epub 2016 Aug 3.

PMID: 27487210

Cell biology: The TORC1 pathway to protein destruction.

Chantranupong L, Sabatini DM.

Nature. 2016 Aug 11;536(7615):155-6. doi: 10.1038/nature18919. Epub 2016 Jul 27.

PMID: 27462809

Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α-glucosidase inhibitor or a Nrf2-inducer.

Strong R, Miller RA, Antebi A, Astle CM, Bogue M, Denzel MS, Fernandez E, Flurkey K, Hamilton KL, Lamming DW, Javors MA, de Magalhães JP, Martinez PA, McCord JM, Miller BF, Müller M, Nelson JF, Ndukum J, Rainger GE, Richardson A, Sabatini DM, Salmon AB, Simpkins JW, Steegenga WT, Nadon NL, Harrison DE.

Aging Cell. 2016 Oct;15(5):872-84. doi: 10.1111/acel.12496. Epub 2016 Jun 16.

PMID: 27312235

Mule Regulates the Intestinal Stem Cell Niche via the Wnt Pathway and Targets EphB3 for Proteasomal and Lysosomal Degradation.

Dominguez-Brauer C, Hao Z, Elia AJ, Fortin JM, Nechanitzky R, Brauer PM, Sheng Y, Mana MD, Chio IIC, Haight J, Pollett A, Cairns R, Tworzyanski L, Inoue S, Reardon C, Marques A, Silvester J, Cox MA, Wakeham A, Yilmaz OH, Sabatini DM, van Es JH, Clevers H, Sato T, Mak TW.

Cell Stem Cell. 2016 Aug 4;19(2):205-216. doi: 10.1016/j.stem.2016.04.002. Epub 2016 May 12.

PMID: 27184401

A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate.

Pacold ME, Brimacombe KR, Chan SH, Rohde JM, Lewis CA, Swier LJ, Possemato R, Chen WW, Sullivan LB, Fiske BP, Cho S, Freinkman E, Birsoy K, Abu-Remaileh M, Shaul YD, Liu CM, Zhou M, Koh MJ, Chung H, Davidson SM, Luengo A, Wang AQ, Xu X, Yasgar A, Liu L, Rai G, Westover KD, Vander Heiden MG, Shen M, Gray NS, Boxer MB, Sabatini DM.

Nat Chem Biol. 2016 Jun;12(6):452-8. doi: 10.1038/nchembio.2070. Epub 2016 Apr 25.

PMID: 27110680

The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway.

Chantranupong L, Scaria SM, Saxton RA, Gygi MP, Shen K, Wyant GA, Wang T, Harper JW, Gygi SP, Sabatini DM.

Cell. 2016 Mar 24;165(1):153-164. doi: 10.1016/j.cell.2016.02.035. Epub 2016 Mar 10.

PMID: 26972053

High-fat diet enhances stemness and tumorigenicity of intestinal progenitors.

Beyaz S, Mana MD, Roper J, Kedrin D, Saadatpour A, Hong SJ, Bauer-Rowe KE, Xifaras ME, Akkad A, Arias E, Pinello L, Katz Y, Shinagare S, Abu-Remaileh M, Mihaylova MM, Lamming DW, Dogum R, Guo G, Bell GW, Selig M, Nielsen GP, Gupta N, Ferrone CR, Deshpande V, Yuan GC, Orkin SH, Sabatini DM, Yilmaz ÖH.

Nature. 2016 Mar 3;531(7592):53-8. doi: 10.1038/nature17173.

PMID: 26935695

Large-Scale Single Guide RNA Library Construction and Use for CRISPR-Cas9-Based Genetic Screens.

Wang T, Lander ES, Sabatini DM.

Cold Spring Harb Protoc. 2016 Mar 1;2016(3):pdb.top086892. doi: 10.1101/pdb.top086892.

PMID: 26933254

Viral Packaging and Cell Culture for CRISPR-Based Screens.

Wang T, Lander ES, Sabatini DM.

Cold Spring Harb Protoc. 2016 Mar 1;2016(3):pdb.prot090811. doi: 10.1101/pdb.prot090811.

PMID: 26933250

Single Guide RNA Library Design and Construction.

Wang T, Lander ES, Sabatini DM.

Cold Spring Harb Protoc. 2016 Mar 1;2016(3):pdb.prot090803. doi: 10.1101/pdb.prot090803.

PMID: 26933249

Mediobasal hypothalamic overexpression of DEPTOR protects against high-fat diet-induced obesity.

Caron A, Labbé SM, Lanfray D, Blanchard PG, Villot R, Roy C, Sabatini DM, Richard D, Laplante M.

Mol Metab. 2015 Dec 8;5(2):102-112. doi: 10.1016/j.molmet.2015.11.005. eCollection 2016 Feb.

PMID: 26909318

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).

Klionsky DJ, et al.

Autophagy. 2016;12(1):1-222. doi: 10.1080/15548627.2015.1100356.

PMID: 26799652

Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma.

Okosun J, Wolfson RL, Wang J, Araf S, Wilkins L, Castellano BM, Escudero-Ibarz L, Al Seraihi AF, Richter J, Bernhart SH, Efeyan A, Iqbal S, Matthews J, Clear A, Guerra-Assunção JA, Bödör C, Quentmeier H, Mansbridge C, Johnson P, Davies A, Strefford JC, Packham G, Barrans S, Jack A, Du MQ, Calaminici M, Lister TA, Auer R, Montoto S, Gribben JG, Siebert R, Chelala C, Zoncu R, Sabatini DM, Fitzgibbon J.

Nat Genet. 2016 Feb;48(2):183-8. doi: 10.1038/ng.3473. Epub 2015 Dec 21.

PMID: 26691987

MERAV: a tool for comparing gene expression across human tissues and cell types.

Shaul YD, Yuan B, Thiru P, Nutter-Upham A, McCallum S, Lanzkron C, Bell GW, Sabatini DM.

Nucleic Acids Res. 2016 Jan 4;44(D1):D560-6. doi: 10.1093/nar/gkv1337. Epub 2015 Nov 30.

PMID: 26626150

Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway.

Saxton RA, Knockenhauer KE, Wolfson RL, Chantranupong L, Pacold ME, Wang T, Schwartz TU, Sabatini DM.

Science. 2016 Jan 1;351(6268):53-8. doi: 10.1126/science.aad2087. Epub 2015 Nov 19.

PMID: 26586190

Identification and characterization of essential genes in the human genome.

Wang T, Birsoy K, Hughes NW, Krupczak KM, Post Y, Wei JJ, Lander ES, Sabatini DM.

Science. 2015 Nov 27;350(6264):1096-101. doi: 10.1126/science.aac7041. Epub 2015 Oct 15.

PMID: 26472758

Sestrin2 is a leucine sensor for the mTORC1 pathway.

Wolfson RL, Chantranupong L, Saxton RA, Shen K, Scaria SM, Cantor JR, Sabatini DM.

Science. 2016 Jan 1;351(6268):43-8. doi: 10.1126/science.aab2674. Epub 2015 Oct 8.

PMID: 26449471

Identification of an oncogenic RAB protein.

Wheeler DB, Zoncu R, Root DE, Sabatini DM, Sawyers CL.

Science. 2015 Oct 9;350(6257):211-7. doi: 10.1126/science.aaa4903. Epub 2015 Sep 3.

PMID: 26338797

Disruption of the Rag-Ragulator Complex by c17orf59 Inhibits mTORC1.

Schweitzer LD, Comb WC, Bar-Peled L, Sabatini DM.

Cell Rep. 2015 Sep 1;12(9):1445-55. doi: 10.1016/j.celrep.2015.07.052. Epub 2015 Aug 20.

PMID: 26299971

An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis.

Birsoy K, Wang T, Chen WW, Freinkman E, Abu-Remaileh M, Sabatini DM.

Cell. 2015 Jul 30;162(3):540-51. doi: 10.1016/j.cell.2015.07.016.

PMID: 26232224

SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance.

Kim D, Fiske BP, Birsoy K, Freinkman E, Kami K, Possemato RL, Chudnovsky Y, Pacold ME, Chen WW, Cantor JR, Shelton LM, Gui DY, Kwon M, Ramkissoon SH, Ligon KL, Kang SW, Snuderl M, Vander Heiden MG, Sabatini DM.

Nature. 2015 Apr 16;520(7547):363-7. doi: 10.1038/nature14363. Epub 2015 Apr 8.

PMID: 25855294

Asymmetric apportioning of aged mitochondria between daughter cells is required for stemness.

Katajisto P, Döhla J, Chaffer CL, Pentinmikko N, Marjanovic N, Iqbal S, Zoncu R, Chen W, Weinberg RA, Sabatini DM.

Science. 2015 Apr 17;348(6232):340-3. doi: 10.1126/science.1260384. Epub 2015 Apr 2.

PMID: 25837514

Nutrient-sensing mechanisms across evolution.

Chantranupong L, Wolfson RL, Sabatini DM.

Cell. 2015 Mar 26;161(1):67-83. doi: 10.1016/j.cell.2015.02.041.

PMID: 25815986

Nutrient-sensing mechanisms and pathways.

Efeyan A, Comb WC, Sabatini DM.

Nature. 2015 Jan 15;517(7534):302-10. doi: 10.1038/nature14190.

PMID: 25592535

Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1.

Wang S, Tsun ZY, Wolfson RL, Shen K, Wyant GA, Plovanich ME, Yuan ED, Jones TD, Chantranupong L, Comb W, Wang T, Bar-Peled L, Zoncu R, Straub C, Kim C, Park J, Sabatini BL, Sabatini DM.

Science. 2015 Jan 9;347(6218):188-94. doi: 10.1126/science.1257132. Epub 2015 Jan 7.

PMID: 25567906

Systematic identification of signaling pathways with potential to confer anticancer drug resistance.

Martz CA, Ottina KA, Singleton KR, Jasper JS, Wardell SE, Peraza-Penton A, Anderson GR, Winter PS, Wang T, Alley HM, Kwong LN, Cooper ZA, Tetzlaff M, Chen PL, Rathmell JC, Flaherty KT, Wargo JA, McDonnell DP, Sabatini DM, Wood KC.

Sci Signal. 2014 Dec 23;7(357):ra121. doi: 10.1126/scisignal.aaa1877.

PMID: 25538079

Response and acquired resistance to everolimus in anaplastic thyroid cancer.

Wagle N, Grabiner BC, Van Allen EM, Amin-Mansour A, Taylor-Weiner A, Rosenberg M, Gray N, Barletta JA, Guo Y, Swanson SJ, Ruan DT, Hanna GJ, Haddad RI, Getz G, Kwiatkowski DJ, Carter SL, Sabatini DM, Jänne PA, Garraway LA, Lorch JH.

N Engl J Med. 2014 Oct 9;371(15):1426-33. doi: 10.1056/NEJMoa1403352.

PMID: 25295501

The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1.

Chantranupong L, Wolfson RL, Orozco JM, Saxton RA, Scaria SM, Bar-Peled L, Spooner E, Isasa M, Gygi SP, Sabatini DM.

Cell Rep. 2014 Oct 9;9(1):1-8. doi: 10.1016/j.celrep.2014.09.014. Epub 2014 Sep 25.

PMID: 25263562

Dihydropyrimidine accumulation is required for the epithelial-mesenchymal transition.

Shaul YD, Freinkman E, Comb WC, Cantor JR, Tam WL, Thiru P, Kim D, Kanarek N, Pacold ME, Chen WW, Bierie B, Possemato R, Reinhardt F, Weinberg RA, Yaffe MB, Sabatini DM.

Cell. 2014 Aug 28;158(5):1094-1109. doi: 10.1016/j.cell.2014.07.032.

PMID: 25171410

Depletion of Rictor, an essential protein component of mTORC2, decreases male lifespan.

Lamming DW, Mihaylova MM, Katajisto P, Baar EL, Yilmaz OH, Hutchins A, Gultekin Y, Gaither R, Sabatini DM.

Aging Cell. 2014 Oct;13(5):911-7. doi: 10.1111/acel.12256. Epub 2014 Jul 25.

PMID: 25059582

The protein synthesis inhibitor blasticidin s enters mammalian cells via leucine-rich repeat-containing protein 8D.

Lee CC, Freinkman E, Sabatini DM, Ploegh HL.

J Biol Chem. 2014 Jun 13;289(24):17124-31. doi: 10.1074/jbc.M114.571257. Epub 2014 Apr 29.

PMID: 24782309

RagA, but not RagB, is essential for embryonic development and adult mice.

Efeyan A, Schweitzer LD, Bilate AM, Chang S, Kirak O, Lamming DW, Sabatini DM.

Dev Cell. 2014 May 12;29(3):321-9. doi: 10.1016/j.devcel.2014.03.017. Epub 2014 Apr 24.

PMID: 24768164

Myeloid-specific Rictor deletion induces M1 macrophage polarization and potentiates in vivo pro-inflammatory response to lipopolysaccharide.

Festuccia WT, Pouliot P, Bakan I, Sabatini DM, Laplante M.

PLoS One. 2014 Apr 16;9(4):e95432. doi: 10.1371/journal.pone.0095432. eCollection 2014.

PMID: 24740015

Regulation of mTORC1 by amino acids.

Bar-Peled L, Sabatini DM.

Trends Cell Biol. 2014 Jul;24(7):400-6. doi: 10.1016/j.tcb.2014.03.003. Epub 2014 Mar 31.

PMID: 24698685

Inhibition of ATPIF1 ameliorates severe mitochondrial respiratory chain dysfunction in mammalian cells.

Chen WW, Birsoy K, Mihaylova MM, Snitkin H, Stasinski I, Yucel B, Bayraktar EC, Carette JE, Clish CB, Brummelkamp TR, Sabatini DD, Sabatini DM.

Cell Rep. 2014 Apr 10;7(1):27-34. doi: 10.1016/j.celrep.2014.02.046. Epub 2014 Mar 27.

PMID: 24685140

Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides.

Birsoy K, Possemato R, Lorbeer FK, Bayraktar EC, Thiru P, Yucel B, Wang T, Chen WW, Clish CB, Sabatini DM.

Nature. 2014 Apr 3;508(7494):108-12. doi: 10.1038/nature13110. Epub 2014 Mar 16.

PMID: 24670634

A diverse array of cancer-associated MTOR mutations are hyperactivating and can predict rapamycin sensitivity.

Grabiner BC, Nardi V, Birsoy K, Possemato R, Shen K, Sinha S, Jordan A, Beck AH, Sabatini DM.

Cancer Discov. 2014 May;4(5):554-63. doi: 10.1158/2159-8290.CD-13-0929. Epub 2014 Mar 14.

PMID: 24631838

Activating mTOR mutations in a patient with an extraordinary response on a phase I trial of everolimus and pazopanib.

Wagle N, Grabiner BC, Van Allen EM, Hodis E, Jacobus S, Supko JG, Stewart M, Choueiri TK, Gandhi L, Cleary JM, Elfiky AA, Taplin ME, Stack EC, Signoretti S, Loda M, Shapiro GI, Sabatini DM, Lander ES, Gabriel SB, Kantoff PW, Garraway LA, Rosenberg JE.

Cancer Discov. 2014 May;4(5):546-53. doi: 10.1158/2159-8290.CD-13-0353. Epub 2014 Mar 13.

PMID: 24625776

Dietary and metabolic control of stem cell function in physiology and cancer.

Mihaylova MM, Sabatini DM, Yilmaz ÖH.

Cell Stem Cell. 2014 Mar 6;14(3):292-305. doi: 10.1016/j.stem.2014.02.008.

PMID: 24607404

The adaptor protein p66Shc inhibits mTOR-dependent anabolic metabolism.

Soliman MA, Abdel Rahman AM, Lamming DW, Birsoy K, Pawling J, Frigolet ME, Lu H, Fantus IG, Pasculescu A, Zheng Y, Sabatini DM, Dennis JW, Pawson T.

Sci Signal. 2014 Feb 18;7(313):ra17. doi: 10.1126/scisignal.2004785.

PMID: 24550542

ZFHX4 interacts with the NuRD core member CHD4 and regulates the glioblastoma tumor-initiating cell state.

Chudnovsky Y, Kim D, Zheng S, Whyte WA, Bansal M, Bray MA, Gopal S, Theisen MA, Bilodeau S, Thiru P, Muffat J, Yilmaz OH, Mitalipova M, Woolard K, Lee J, Nishimura R, Sakata N, Fine HA, Carpenter AE, Silver SJ, Verhaak RG, Califano A, Young RA, Ligon KL, Mellinghoff IK, Root DE, Sabatini DM, Hahn WC, Chheda MG.

Cell Rep. 2014 Jan 30;6(2):313-24. doi: 10.1016/j.celrep.2013.12.032. Epub 2014 Jan 16.

PMID: 24440720

Genetic screens in human cells using the CRISPR-Cas9 system.

Wang T, Wei JJ, Sabatini DM, Lander ES.

Science. 2014 Jan 3;343(6166):80-4. doi: 10.1126/science.1246981. Epub 2013 Dec 12.

PMID: 24336569

The TSC-mTOR pathway regulates macrophage polarization.

Byles V, Covarrubias AJ, Ben-Sahra I, Lamming DW, Sabatini DM, Manning BD, Horng T.

Nat Commun. 2013;4:2834. doi: 10.1038/ncomms3834.

PMID: 24280772

A CREB3-ARF4 signalling pathway mediates the response to Golgi stress and susceptibility to pathogens.

Reiling JH, Olive AJ, Sanyal S, Carette JE, Brummelkamp TR, Ploegh HL, Starnbach MN, Sabatini DM.

Nat Cell Biol. 2013 Dec;15(12):1473-85. doi: 10.1038/ncb2865. Epub 2013 Nov 3.

PMID: 24185178

The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1.

Tsun ZY, Bar-Peled L, Chantranupong L, Zoncu R, Wang T, Kim C, Spooner E, Sabatini DM.

Mol Cell. 2013 Nov 21;52(4):495-505. doi: 10.1016/j.molcel.2013.09.016. Epub 2013 Oct 3.

PMID: 24095279

Hepatic signaling by the mechanistic target of rapamycin complex 2 (mTORC2).

Lamming DW, Demirkan G, Boylan JM, Mihaylova MM, Peng T, Ferreira J, Neretti N, Salomon A, Sabatini DM, Gruppuso PA.

FASEB J. 2014 Jan;28(1):300-15. doi: 10.1096/fj.13-237743. Epub 2013 Sep 26.

PMID: 24072782

A Central role for mTOR in lipid homeostasis.

Lamming DW, Sabatini DM.

Cell Metab. 2013 Oct 1;18(4):465-9. doi: 10.1016/j.cmet.2013.08.002. Epub 2013 Aug 22.

PMID: 23973332

Rapamycin doses sufficient to extend lifespan do not compromise muscle mitochondrial content or endurance.

Ye L, Widlund AL, Sims CA, Lamming DW, Guan Y, Davis JG, Sabatini DM, Harrison DE, Vang O, Baur JA.

Aging (Albany NY). 2013 Jul;5(7):539-50. doi: 10.18632/aging.100576.

PMID: 23929887

mTORC1 phosphorylation sites encode their sensitivity to starvation and rapamycin.

Kang SA, Pacold ME, Cervantes CL, Lim D, Lou HJ, Ottina K, Gray NS, Turk BE, Yaffe MB, Sabatini DM.

Science. 2013 Jul 26;341(6144):1236566. doi: 10.1126/science.1236566.

PMID: 23888043

Nutrients and growth factors in mTORC1 activation.

Efeyan A, Sabatini DM.

Biochem Soc Trans. 2013 Aug;41(4):902-5. doi: 10.1042/BST20130063.

PMID: 23863153

The bromodomain protein Brd4 insulates chromatin from DNA damage signalling.

Floyd SR, Pacold ME, Huang Q, Clarke SM, Lam FC, Cannell IG, Bryson BD, Rameseder J, Lee MJ, Blake EJ, Fydrych A, Ho R, Greenberger BA, Chen GC, Maffa A, Del Rosario AM, Root DE, Carpenter AE, Hahn WC, Sabatini DM, Chen CC, White FM, Bradner JE, Yaffe MB.

Nature. 2013 Jun 13;498(7453):246-50. doi: 10.1038/nature12147. Epub 2013 Jun 2.

PMID: 23728299

A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1.

Bar-Peled L, Chantranupong L, Cherniack AD, Chen WW, Ottina KA, Grabiner BC, Spear ED, Carter SL, Meyerson M, Sabatini DM.

Science. 2013 May 31;340(6136):1100-6. doi: 10.1126/science.1232044.

PMID: 23723238

Pten-null tumors cohabiting the same lung display differential AKT activation and sensitivity to dietary restriction.

Curry NL, Mino-Kenudson M, Oliver TG, Yilmaz OH, Yilmaz VO, Moon JY, Jacks T, Sabatini DM, Kalaany NY.

Cancer Discov. 2013 Aug;3(8):908-21. doi: 10.1158/2159-8290.CD-12-0507. Epub 2013 May 29.

PMID: 23719831

Young and old genetically heterogeneous HET3 mice on a rapamycin diet are glucose intolerant but insulin sensitive.

Lamming DW, Ye L, Astle CM, Baur JA, Sabatini DM, Harrison DE.

Aging Cell. 2013 Aug;12(4):712-8. doi: 10.1111/acel.12097. Epub 2013 Jun 7.

PMID: 23648089

Regulation of mTORC1 and its impact on gene expression at a glance.

Laplante M, Sabatini DM.

J Cell Sci. 2013 Apr 15;126(Pt 8):1713-9. doi: 10.1242/jcs.125773. Epub 2013 May 2.

PMID: 23641065

Calorie restriction in humans inhibits the PI3K/AKT pathway and induces a younger transcription profile.

Mercken EM, Crosby SD, Lamming DW, JeBailey L, Krzysik-Walker S, Villareal DT, Capri M, Franceschi C, Zhang Y, Becker K, Sabatini DM, de Cabo R, Fontana L.

Aging Cell. 2013 Aug;12(4):645-51. doi: 10.1111/acel.12088. Epub 2013 Jun 5.

PMID: 23601134

Rapalogs and mTOR inhibitors as anti-aging therapeutics.

Lamming DW, Ye L, Sabatini DM, Baur JA.

J Clin Invest. 2013 Mar;123(3):980-9. doi: 10.1172/JCI64099. Epub 2013 Mar 1.

PMID: 23454761

Characterization of Torin2, an ATP-competitive inhibitor of mTOR, ATM, and ATR.

Liu Q, Xu C, Kirubakaran S, Zhang X, Hur W, Liu Y, Kwiatkowski NP, Wang J, Westover KD, Gao P, Ercan D, Niepel M, Thoreen CC, Kang SA, Patricelli MP, Wang Y, Tupper T, Altabef A, Kawamura H, Held KD, Chou DM, Elledge SJ, Janne PA, Wong KK, Sabatini DM, Gray NS.

Cancer Res. 2013 Apr 15;73(8):2574-86. doi: 10.1158/0008-5472.CAN-12-1702. Epub 2013 Feb 22.

PMID: 23436801

Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival.

Efeyan A, Zoncu R, Chang S, Gumper I, Snitkin H, Wolfson RL, Kirak O, Sabatini DD, Sabatini DM.

Nature. 2013 Jan 31;493(7434):679-83. doi: 10.1038/nature11745. Epub 2012 Dec 23.

PMID: 23263183

SnapShot: mTORC1 signaling at the lysosomal surface.

Bar-Peled L, Sabatini DM.

Cell. 2012 Dec 7;151(6):1390-1390.e1. doi: 10.1016/j.cell.2012.11.038.

PMID: 23217718 .

MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors.

Birsoy K, Wang T, Possemato R, Yilmaz OH, Koch CE, Chen WW, Hutchins AW, Gultekin Y, Peterson TR, Carette JE, Brummelkamp TR, Clish CB, Sabatini DM.

Nat Genet. 2013 Jan;45(1):104-8. doi: 10.1038/ng.2471. Epub 2012 Dec 2.

PMID: 23202129

Cancer cell metabolism: one hallmark, many faces.

Cantor JR, Sabatini DM.

Cancer Discov. 2012 Oct;2(10):881-98. doi: 10.1158/2159-8290.CD-12-0345. Epub 2012 Sep 25.

PMID: 23009760

Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1.

Bar-Peled L, Schweitzer LD, Zoncu R, Sabatini DM.

Cell. 2012 Sep 14;150(6):1196-208. doi: 10.1016/j.cell.2012.07.032.

PMID: 22980980

Rapamycin has a biphasic effect on insulin sensitivity in C2C12 myotubes due to sequential disruption of mTORC1 and mTORC2.

Ye L, Varamini B, Lamming DW, Sabatini DM, Baur JA.

Front Genet. 2012 Sep 11;3:177. doi: 10.3389/fgene.2012.00177. eCollection 2012.

PMID: 22973301

Guidelines for the use and interpretation of assays for monitoring autophagy.

Klionsky DJ, et al.

Autophagy. 2012 Apr;8(4):445-544. doi: 10.4161/auto.19496.

PMID: 22966490

DEPTOR cell-autonomously promotes adipogenesis, and its expression is associated with obesity.

Laplante M, Horvat S, Festuccia WT, Birsoy K, Prevorsek Z, Efeyan A, Sabatini DM.

Cell Metab. 2012 Aug 8;16(2):202-12. doi: 10.1016/j.cmet.2012.07.008.

PMID: 22883231

Untuning the tumor metabolic machine: Targeting cancer metabolism: a bedside lesson.

Birsoy K, Sabatini DM, Possemato R.

Nat Med. 2012 Jul 6;18(7):1022-3. doi: 10.1038/nm.2870.

PMID: 22772555

Amino acids and mTORC1: from lysosomes to disease.

Efeyan A, Zoncu R, Sabatini DM.

Trends Mol Med. 2012 Sep;18(9):524-33. doi: 10.1016/j.molmed.2012.05.007. Epub 2012 Jun 28.

PMID: 22749019

mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake.

Yilmaz ÖH, Katajisto P, Lamming DW, Gültekin Y, Bauer-Rowe KE, Sengupta S, Birsoy K, Dursun A, Yilmaz VO, Selig M, Nielsen GP, Mino-Kenudson M, Zukerberg LR, Bhan AK, Deshpande V, Sabatini DM.

Nature. 2012 Jun 28;486(7404):490-5. doi: 10.1038/nature11163.

PMID: 22722868

Pharmacologic Means of Extending Lifespan.

Lamming DW, Sabatini DM, Baur JA.

J Clin Exp Pathol. 2012 May 17;Suppl 4:7327. doi: 10.4172/2161-0681.S4-002.

PMID: 25379357

MicroSCALE screening reveals genetic modifiers of therapeutic response in melanoma.

Wood KC, Konieczkowski DJ, Johannessen CM, Boehm JS, Tamayo P, Botvinnik OB, Mesirov JP, Hahn WC, Root DE, Garraway LA, Sabatini DM.

Sci Signal. 2012 May 15;5(224):rs4. doi: 10.1126/scisignal.2002612.

PMID: 22589389

TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO.

Robida-Stubbs S, Glover-Cutter K, Lamming DW, Mizunuma M, Narasimhan SD, Neumann-Haefelin E, Sabatini DM, Blackwell TK.

Cell Metab. 2012 May 2;15(5):713-24. doi: 10.1016/j.cmet.2012.04.007.

PMID: 22560223

A unifying model for mTORC1-mediated regulation of mRNA translation.

Thoreen CC, Chantranupong L, Keys HR, Wang T, Gray NS, Sabatini DM.

Nature. 2012 May 2;485(7396):109-13. doi: 10.1038/nature11083.

PMID: 22552098

mTOR signaling in growth control and disease.

Laplante M, Sabatini DM.

Cell. 2012 Apr 13;149(2):274-93. doi: 10.1016/j.cell.2012.03.017.

PMID: 22500797

Selective ATP-competitive inhibitors of TOR suppress rapamycin-insensitive function of TORC2 in Saccharomyces cerevisiae.

Liu Q, Ren T, Fresques T, Oppliger W, Niles BJ, Hur W, Sabatini DM, Hall MN, Powers T, Gray NS.

ACS Chem Biol. 2012 Jun 15;7(6):982-7. doi: 10.1021/cb300058v. Epub 2012 Apr 18.

PMID: 22496512

Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity.

Lamming DW, Ye L, Katajisto P, Goncalves MD, Saitoh M, Stevens DM, Davis JG, Salmon AB, Richardson A, Ahima RS, Guertin DA, Sabatini DM, Baur JA.

Science. 2012 Mar 30;335(6076):1638-43. doi: 10.1126/science.1215135.

PMID: 22461615

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB.

Settembre C, Zoncu R, Medina DL, Vetrini F, Erdin S, Erdin S, Huynh T, Ferron M, Karsenty G, Vellard MC, Facchinetti V, Sabatini DM, Ballabio A.

EMBO J. 2012 Mar 7;31(5):1095-108. doi: 10.1038/emboj.2012.32. Epub 2012 Feb 17.

PMID: 22343943

Kinome-wide selectivity profiling of ATP-competitive mammalian target of rapamycin (mTOR) inhibitors and characterization of their binding kinetics.

Liu Q, Kirubakaran S, Hur W, Niepel M, Westover K, Thoreen CC, Wang J, Ni J, Patricelli MP, Vogel K, Riddle S, Waller DL, Traynor R, Sanda T, Zhao Z, Kang SA, Zhao J, Look AT, Sorger PK, Sabatini DM, Gray NS.

J Biol Chem. 2012 Mar 23;287(13):9742-9752. doi: 10.1074/jbc.M111.304485. Epub 2012 Jan 5.

PMID: 22223645

mTOR Signaling.

Laplante M, Sabatini DM.

Cold Spring Harb Perspect Biol. 2012 Feb 1;4(2):a011593. doi: 10.1101/cshperspect.a011593.

PMID: 22129599

Development of ATP-competitive mTOR inhibitors.

Liu Q, Kang SA, Thoreen CC, Hur W, Wang J, Chang JW, Markhard A, Zhang J, Sim T, Sabatini DM, Gray NS.

Methods Mol Biol. 2012;821:447-60. doi: 10.1007/978-1-61779-430-8_29.

PMID: 22125084

mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase.

Zoncu R, Bar-Peled L, Efeyan A, Wang S, Sancak Y, Sabatini DM.

Science. 2011 Nov 4;334(6056):678-83. doi: 10.1126/science.1207056.

PMID: 22053050

Postprandial hepatic lipid metabolism requires signaling through Akt2 independent of the transcription factors FoxA2, FoxO1, and SREBP1c.

Wan M, Leavens KF, Saleh D, Easton RM, Guertin DA, Peterson TR, Kaestner KH, Sabatini DM, Birnbaum MJ.

Cell Metab. 2011 Oct 5;14(4):516-27. doi: 10.1016/j.cmet.2011.09.001.

PMID: 21982711

mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway.

Peterson TR, Sengupta SS, Harris TE, Carmack AE, Kang SA, Balderas E, Guertin DA, Madden KL, Carpenter AE, Finck BN, Sabatini DM.

Cell. 2011 Aug 5;146(3):408-20. doi: 10.1016/j.cell.2011.06.034.

PMID: 21816276

Functional genomics reveal that the serine synthesis pathway is essential in breast cancer.

Possemato R, Marks KM, Shaul YD, Pacold ME, Kim D, Birsoy K, Sethumadhavan S, Woo HK, Jang HG, Jha AK, Chen WW, Barrett FG, Stransky N, Tsun ZY, Cowley GS, Barretina J, Kalaany NY, Hsu PP, Ottina K, Chan AM, Yuan B, Garraway LA, Root DE, Mino-Kenudson M, Brachtel EF, Driggers EM, Sabatini DM.

Nature. 2011 Aug 18;476(7360):346-50. doi: 10.1038/nature10350.

PMID: 21760589

A haploid genetic screen identifies the major facilitator domain containing 2A (MFSD2A) transporter as a key mediator in the response to tunicamycin.

Reiling JH, Clish CB, Carette JE, Varadarajan M, Brummelkamp TR, Sabatini DM.

Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):11756-65. doi: 10.1073/pnas.1018098108. Epub 2011 Jun 15.

PMID: 21677192

The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling.

Hsu PP, Kang SA, Rameseder J, Zhang Y, Ottina KA, Lim D, Peterson TR, Choi Y, Gray NS, Yaffe MB, Marto JA, Sabatini DM.

Science. 2011 Jun 10;332(6035):1317-22. doi: 10.1126/science.1199498.

PMID: 21659604

A radical role for TOR in longevity.

Lamming DW, Sabatini DM.

Cell Metab. 2011 Jun 8;13(6):617-8. doi: 10.1016/j.cmet.2011.05.006.

PMID: 21641542

Discovery and optimization of potent and selective benzonaphthyridinone analogs as small molecule mTOR inhibitors with improved mouse microsome stability.

Liu Q, Wang J, Kang SA, Thoreen CC, Hur W, Choi HG, Waller DL, Sim T, Sabatini DM, Gray NS.

Bioorg Med Chem Lett. 2011 Jul 1;21(13):4036-40. doi: 10.1016/j.bmcl.2011.04.129. Epub 2011 May 7.

PMID: 21621413

Cell biology. The TASCC of secretion.

Zoncu R, Sabatini DM.

Science. 2011 May 20;332(6032):923-5. doi: 10.1126/science.1207552.

PMID: 2159698

Defective regulation of autophagy upon leucine deprivation reveals a targetable liability of human melanoma cells in vitro and in vivo.

Sheen JH, Zoncu R, Kim D, Sabatini DM.

Cancer Cell. 2011 May 17;19(5):613-28. doi: 10.1016/j.ccr.2011.03.012.

PMID: 21575862

Discovery of 9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one (Torin2) as a potent, selective, and orally available mammalian target of rapamycin (mTOR) inhibitor for treatment of cancer.

Liu Q, Wang J, Kang SA, Thoreen CC, Hur W, Ahmed T, Sabatini DM, Gray NS.

J Med Chem. 2011 Mar 10;54(5):1473-80. doi: 10.1021/jm101520v. Epub 2011 Feb 15.

PMID: 21322566

Genome-scale RNAi on living-cell microarrays identifies novel regulators of Drosophila melanogaster TORC1-S6K pathway signaling.

Lindquist RA, Ottina KA, Wheeler DB, Hsu PP, Thoreen CC, Guertin DA, Ali SM, Sengupta S, Shaul YD, Lamprecht MR, Madden KL, Papallo AR, Jones TR, Sabatini DM, Carpenter AE.

Genome Res. 2011 Mar;21(3):433-46. doi: 10.1101/gr.111492.110. Epub 2011 Jan 14.

PMID: 21239477

mTORC1 controls fasting-induced ketogenesis and its modulation by ageing.

Sengupta S, Peterson TR, Laplante M, Oh S, Sabatini DM.

Nature. 2010 Dec 23;468(7327):1100-4. doi: 10.1038/nature09584.

PMID: 21179166

mTOR: from growth signal integration to cancer, diabetes and ageing.

Zoncu R, Efeyan A, Sabatini DM.

Nat Rev Mol Cell Biol. 2011 Jan;12(1):21-35. doi: 10.1038/nrm3025. Epub 2010 Dec 15.

PMID: 21157483

Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress.

Sengupta S, Peterson TR, Sabatini DM.

Mol Cell. 2010 Oct 22;40(2):310-22. doi: 10.1016/j.molcel.2010.09.026.

PMID: 20965424

Discovery of 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one as a highly potent, selective mammalian target of rapamycin (mTOR) inhibitor for the treatment of cancer.

Liu Q, Chang JW, Wang J, Kang SA, Thoreen CC, Markhard A, Hur W, Zhang J, Sim T, Sabatini DM, Gray NS.

J Med Chem. 2010 Oct 14;53(19):7146-55. doi: 10.1021/jm101144f.

PMID: 20860370

Native capillary isoelectric focusing for the separation of protein complex isoforms and subcomplexes.

Fonslow BR, Kang SA, Gestaut DR, Graczyk B, Davis TN, Sabatini DM, Yates JR 3rd.

Anal Chem. 2010 Aug 1;82(15):6643-51. doi: 10.1021/ac101235k.

PMID: 20614870

Structure of the human mTOR complex I and its implications for rapamycin inhibition.

Yip CK, Murata K, Walz T, Sabatini DM, Kang SA.

Mol Cell. 2010 Jun 11;38(5):768-74. doi: 10.1016/j.molcel.2010.05.017.

PMID: 20542007

Functional genomics, proteomics, and regulatory DNA analysis in isogenic settings using zinc finger nuclease-driven transgenesis into a safe harbor locus in the human genome.

DeKelver RC, Choi VM, Moehle EA, Paschon DE, Hockemeyer D, Meijsing SH, Sancak Y, Cui X, Steine EJ, Miller JC, Tam P, Bartsevich VV, Meng X, Rupniewski I, Gopalan SM, Sun HC, Pitz KJ, Rock JM, Zhang L, Davis GD, Rebar EJ, Cheeseman IM, Yamamoto KR, Sabatini DM, Jaenisch R, Gregory PD, Urnov FD.

Genome Res. 2010 Aug;20(8):1133-42. doi: 10.1101/gr.106773.110. Epub 2010 May 27.

PMID: 20508142

Rictor phosphorylation on the Thr-1135 site does not require mammalian target of rapamycin complex 2.

Boulbes D, Chen CH, Shaikenov T, Agarwal NK, Peterson TR, Addona TA, Keshishian H, Carr SA, Magnuson MA, Sabatini DM, Sarbassov dos D.

Mol Cancer Res. 2010 Jun;8(6):896-906. doi: 10.1158/1541-7786.MCR-09-0409. Epub 2010 May 25.

PMID: 20501647

Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids.

Sancak Y, Bar-Peled L, Zoncu R, Markhard AL, Nada S, Sabatini DM.

Cell. 2010 Apr 16;141(2):290-303. doi: 10.1016/j.cell.2010.02.024. Epub 2010 Apr 8.

PMID: 20381137

mTORC1 activates SREBP-1c and uncouples lipogenesis from gluconeogenesis.

Laplante M, Sabatini DM.

Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3281-2. doi: 10.1073/pnas.1000323107. Epub 2010 Feb 18.

PMID: 20167806

An emerging role of mTOR in lipid biosynthesis.

Laplante M, Sabatini DM.

Curr Biol. 2009 Dec 1;19(22):R1046-52. doi: 10.1016/j.cub.2009.09.058.

PMID: 19948145

mTOR and cancer: many loops in one pathway.

Efeyan A, Sabatini DM.

Curr Opin Cell Biol. 2010 Apr;22(2):169-76. doi: 10.1016/j.ceb.2009.10.007. Epub 2009 Nov 27.

PMID: 19945836

Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1.

Barbie DA, Tamayo P, Boehm JS, Kim SY, Moody SE, Dunn IF, Schinzel AC, Sandy P, Meylan E, Scholl C, Fröhling S, Chan EM, Sos ML, Michel K, Mermel C, Silver SJ, Weir BA, Reiling JH, Sheng Q, Gupta PB, Wadlow RC, Le H, Hoersch S, Wittner BS, Ramaswamy S, Livingston DM, Sabatini DM, Meyerson M, Thomas RK, Lander ES, Mesirov JP, Root DE, Gilliland DG, Jacks T, Hahn WC.

Nature. 2009 Nov 5;462(7269):108-12. doi: 10.1038/nature08460. Epub 2009 Oct 21.

PMID: 19847166

mTOR signaling at a glance.

Laplante M, Sabatini DM.

J Cell Sci. 2009 Oct 15;122(Pt 20):3589-94. doi: 10.1242/jcs.051011.

PMID: 19812304

Growth signaling at the nexus of stem cell life and death.

Wood KC, Sabatini DM.

Cell Stem Cell. 2009 Sep 4;5(3):232-4. doi: 10.1016/j.stem.2009.08.008.

PMID: 19733530

DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival.

Peterson TR, Laplante M, Thoreen CC, Sancak Y, Kang SA, Kuehl WM, Gray NS, Sabatini DM.

Cell. 2009 May 29;137(5):873-86. doi: 10.1016/j.cell.2009.03.046. Epub 2009 May 14.

PMID: 19446321

Rapamycin inhibits mTORC1, but not completely.

Thoreen CC, Sabatini DM.

Autophagy. 2009 Jul;5(5):725-6. doi: 10.4161/auto.5.5.8504. Epub 2009 Jul 22.

PMID: 19395872

The pharmacology of mTOR inhibition.

Guertin DA, Sabatini DM.

Sci Signal. 2009 Apr 21;2(67):pe24. doi: 10.1126/scisignal.267pe24.

PMID: 19383975

Tumours with PI3K activation are resistant to dietary restriction.

Kalaany NY, Sabatini DM.

Nature. 2009 Apr 9;458(7239):725-31. doi: 10.1038/nature07782. Epub 2009 Mar 11.

PMID: 19279572

Scoring diverse cellular morphologies in image-based screens with iterative feedback and machine learning.

Jones TR, Carpenter AE, Lamprecht MR, Moffat J, Silver SJ, Grenier JK, Castoreno AB, Eggert US, Root DE, Golland P, Sabatini DM.

Proc Natl Acad Sci U S A. 2009 Feb 10;106(6):1826-31. doi: 10.1073/pnas.0808843106. Epub 2009 Feb 2.

PMID: 19188593

mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice.

Guertin DA, Stevens DM, Saitoh M, Kinkel S, Crosby K, Sheen JH, Mullholland DJ, Magnuson MA, Wu H, Sabatini DM.

Cancer Cell. 2009 Feb 3;15(2):148-59. doi: 10.1016/j.ccr.2008.12.017.

PMID: 19185849

An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1.

Thoreen CC, Kang SA, Chang JW, Liu Q, Zhang J, Gao Y, Reichling LJ, Sim T, Sabatini DM, Gray NS.

J Biol Chem. 2009 Mar 20;284(12):8023-32. doi: 10.1074/jbc.M900301200. Epub 2009 Jan 15.

PMID: 19150980

Rag proteins regulate amino-acid-induced mTORC1 signalling.

Sancak Y, Sabatini DM.

Biochem Soc Trans. 2009 Feb;37(Pt 1):289-90. doi: 10.1042/BST0370289.

PMID: 19143648

Highly parallel identification of essential genes in cancer cells.

Luo B, Cheung HW, Subramanian A, Sharifnia T, Okamoto M, Yang X, Hinkle G, Boehm JS, Beroukhim R, Weir BA, Mermel C, Barbie DA, Awad T, Zhou X, Nguyen T, Piqani B, Li C, Golub TR, Meyerson M, Hacohen N, Hahn WC, Lander ES, Sabatini DM, Root DE.

Proc Natl Acad Sci U S A. 2008 Dec 23;105(51):20380-5. doi: 10.1073/pnas.0810485105. Epub 2008 Dec 17.

PMID: 19091943

CellProfiler Analyst: data exploration and analysis software for complex image-based screens.

Jones TR, Kang IH, Wheeler DB, Lindquist RA, Papallo A, Sabatini DM, Golland P, Carpenter AE.

BMC Bioinformatics. 2008 Nov 15;9:482. doi: 10.1186/1471-2105-9-482.

PMID: 19014601

Cancer cell metabolism: Warburg and beyond.

Hsu PP, Sabatini DM.

Cell. 2008 Sep 5;134(5):703-7. doi: 10.1016/j.cell.2008.08.021.

PMID: 18775299

The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1.

Sancak Y, Peterson TR, Shaul YD, Lindquist RA, Thoreen CC, Bar-Peled L, Sabatini DM.

Science. 2008 Jun 13;320(5882):1496-501. doi: 10.1126/science.1157535. Epub 2008 May 22.

PMID: 18497260

Increased mTORC1 signaling UPRegulates stress.

Reiling JH, Sabatini DM.

Mol Cell. 2008 Mar 14;29(5):533-5. doi: 10.1016/j.molcel.2008.02.011.

PMID: 18342598

Defining the role of mTOR in cancer.

Guertin DA, Sabatini DM.

Cancer Cell. 2007 Jul;12(1):9-22. doi: 10.1016/j.ccr.2007.05.008.

PMID: 17613433

PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase.

Sancak Y, Thoreen CC, Peterson TR, Lindquist RA, Kang SA, Spooner E, Carr SA, Sabatini DM.

Mol Cell. 2007 Mar 23;25(6):903-15. doi: 10.1016/j.molcel.2007.03.003.

PMID: 17386266

Off-target effects associated with long dsRNAs in Drosophila RNAi screens.

Moffat J, Reiling JH, Sabatini DM.

Trends Pharmacol Sci. 2007 Apr;28(4):149-51. doi: 10.1016/j.tips.2007.02.009. Epub 2007 Mar 9.

PMID: 17350110

CellProfiler: free, versatile software for automated biological image analysis.

Lamprecht MR, Sabatini DM, Carpenter AE.

Biotechniques. 2007 Jan;42(1):71-5. doi: 10.2144/000112257.

PMID: 17269487

Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML.

Zeng Z, Sarbassov dos D, Samudio IJ, Yee KW, Munsell MF, Ellen Jackson C, Giles FJ, Sabatini DM, Andreeff M, Konopleva M.

Blood. 2007 Apr 15;109(8):3509-12. doi: 10.1182/blood-2006-06-030833. Epub 2006 Dec 19.

PMID: 17179228

Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1.

Guertin DA, Stevens DM, Thoreen CC, Burds AA, Kalaany NY, Moffat J, Brown M, Fitzgerald KJ, Sabatini DM.

Dev Cell. 2006 Dec;11(6):859-71. doi: 10.1016/j.devcel.2006.10.007.

PMID: 17141160

CellProfiler: image analysis software for identifying and quantifying cell phenotypes.

Carpenter AE, Jones TR, Lamprecht MR, Clarke C, Kang IH, Friman O, Guertin DA, Chang JH, Lindquist RA, Moffat J, Golland P, Sabatini DM.

Genome Biol. 2006;7(10):R100. doi: 10.1186/gb-2006-7-10-r100. Epub 2006 Oct 31.

PMID: 17076895

Minimizing the risk of reporting false positives in large-scale RNAi screens.

Echeverri CJ, Beachy PA, Baum B, Boutros M, Buchholz F, Chanda SK, Downward J, Ellenberg J, Fraser AG, Hacohen N, Hahn WC, Jackson AL, Kiger A, Linsley PS, Lum L, Ma Y, Mathey-Prévôt B, Root DE, Sabatini DM, Taipale J, Perrimon N, Bernards R.

Nat Methods. 2006 Oct;3(10):777-9. doi: 10.1038/nmeth1006-777.

PMID: 16990807

Genome-scale loss-of-function screening with a lentiviral RNAi library.

Root DE, Hacohen N, Hahn WC, Lander ES, Sabatini DM.

Nat Methods. 2006 Sep;3(9):715-9. doi: 10.1038/nmeth924.

PMID: 16929317

mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s.

Frias MA, Thoreen CC, Jaffe JD, Schroder W, Sculley T, Carr SA, Sabatini DM.

Curr Biol. 2006 Sep 19;16(18):1865-70. doi: 10.1016/j.cub.2006.08.001. Epub 2006 Aug 17.

PMID: 16919458

mTOR and cancer: insights into a complex relationship.

Sabatini DM.

Nat Rev Cancer. 2006 Sep;6(9):729-34. doi: 10.1038/nrc1974. Epub 2006 Aug 17.

PMID: 16915295

Functional genomics identifies TOR-regulated genes that control growth and division.

Guertin DA, Guntur KV, Bell GW, Thoreen CC, Sabatini DM.

Curr Biol. 2006 May 23;16(10):958-70. doi: 10.1016/j.cub.2006.03.084.

PMID: 16713952

Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB.

Sarbassov DD, Ali SM, Sengupta S, Sheen JH, Hsu PP, Bagley AF, Markhard AL, Sabatini DM.

Mol Cell. 2006 Apr 21;22(2):159-68. doi: 10.1016/j.molcel.2006.03.029. Epub 2006 Apr 6.

PMID: 16603397

A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen.

Moffat J, Grueneberg DA, Yang X, Kim SY, Kloepfer AM, Hinkle G, Piqani B, Eisenhaure TM, Luo B, Grenier JK, Carpenter AE, Foo SY, Stewart SA, Stockwell BR, Hacohen N, Hahn WC, Lander ES, Sabatini DM, Root DE.

Cell. 2006 Mar 24;124(6):1283-98. doi: 10.1016/j.cell.2006.01.040.

PMID: 16564017

Building mammalian signalling pathways with RNAi screens.

Moffat J, Sabatini DM.

Nat Rev Mol Cell Biol. 2006 Mar;7(3):177-87. doi: 10.1038/nrm1860.

PMID: 16496020

Microarrays of lentiviruses for gene function screens in immortalized and primary cells.

Bailey SN, Ali SM, Carpenter AE, Higgins CO, Sabatini DM.

Nat Methods. 2006 Feb;3(2):117-22. doi: 10.1038/nmeth848.

PMID: 16432521

eIF3: a connecTOR of S6K1 to the translation preinitiation complex.

Peterson TR, Sabatini DM.

Mol Cell. 2005 Dec 9;20(5):655-7. doi: 10.1016/j.molcel.2005.11.016.

PMID: 16337588

Growing roles for the mTOR pathway.

Sarbassov DD, Ali SM, Sabatini DM.

Curr Opin Cell Biol. 2005 Dec;17(6):596-603. doi: 10.1016/j.ceb.2005.09.009. Epub 2005 Oct 13.

PMID: 16226444

Redox regulation of the nutrient-sensitive raptor-mTOR pathway and complex.

Sarbassov DD, Sabatini DM.

J Biol Chem. 2005 Nov 25;280(47):39505-9. doi: 10.1074/jbc.M506096200. Epub 2005 Sep 23.

PMID: 16183647

AMPK and p53 help cells through lean times.

Thoreen CC, Sabatini DM.

Cell Metab. 2005 May;1(5):287-8. doi: 10.1016/j.cmet.2005.04.009.

PMID: 16054073

An expanding role for mTOR in cancer.

Guertin DA, Sabatini DM.

Trends Mol Med. 2005 Aug;11(8):353-61. doi: 10.1016/j.molmed.2005.06.007.

PMID: 16002336

Cell microarrays and RNA interference chip away at gene function.

Wheeler DB, Carpenter AE, Sabatini DM.

Nat Genet. 2005 Jun;37 Suppl:S25-30. doi: 10.1038/ng1560.

PMID: 15920526

Structure of S6 kinase 1 determines whether raptor-mTOR or rictor-mTOR phosphorylates its hydrophobic motif site.

Ali SM, Sabatini DM.

J Biol Chem. 2005 May 20;280(20):19445-8. doi: 10.1074/jbc.C500125200. Epub 2005 Apr 4.

PMID: 15809305

RNAi living-cell microarrays for loss-of-function screens in Drosophila melanogaster cells.

Wheeler DB, Bailey SN, Guertin DA, Carpenter AE, Higgins CO, Sabatini DM.

Nat Methods. 2004 Nov;1(2):127-32. doi: 10.1038/nmeth711. Epub 2004 Oct 21.

PMID: 15782175

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex.

Sarbassov DD, Guertin DA, Ali SM, Sabatini DM.

Science. 2005 Feb 18;307(5712):1098-101. doi: 10.1126/science.1106148.

PMID: 15718470

Microarrays of small molecules embedded in biodegradable polymers for use in mammalian cell-based screens.

Bailey SN, Sabatini DM, Stockwell BR.

Proc Natl Acad Sci U S A. 2004 Nov 16;101(46):16144-9. doi: 10.1073/pnas.0404425101. Epub 2004 Nov 8.

PMID: 15534212

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton.

Sarbassov DD, Ali SM, Kim DH, Guertin DA, Latek RR, Erdjument-Bromage H, Tempst P, Sabatini DM.

Curr Biol. 2004 Jul 27;14(14):1296-302. doi: 10.1016/j.cub.2004.06.054.

PMID: 15268862

Huntingtin aggregates ask to be eaten.

Thoreen CC, Sabatini DM.

Nat Genet. 2004 Jun;36(6):553-4. doi: 10.1038/ng0604-553.

PMID: 15167929

Systematic genome-wide screens of gene function.

Carpenter AE, Sabatini DM.

Nat Rev Genet. 2004 Jan;5(1):11-22. doi: 10.1038/nrg1248.

PMID: 14708012

Raptor and mTOR: subunits of a nutrient-sensitive complex.

Kim DH, Sabatini DM.

Curr Top Microbiol Immunol. 2004;279:259-70. doi: 10.1007/978-3-642-18930-2_15.

PMID: 14560962

TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function.

Schalm SS, Fingar DC, Sabatini DM, Blenis J.

Curr Biol. 2003 May 13;13(10):797-806. doi: 10.1016/s0960-9822(03)00329-4.

PMID: 12747827

GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR.

Kim DH, Sarbassov DD, Ali SM, Latek RR, Guntur KV, Erdjument-Bromage H, Tempst P, Sabatini DM.

Mol Cell. 2003 Apr;11(4):895-904. doi: 10.1016/s1097-2765(03)00114-x.

PMID: 12718876

Lentivirus-delivered stable gene silencing by RNAi in primary cells.

Stewart SA, Dykxhoorn DM, Palliser D, Mizuno H, Yu EY, An DS, Sabatini DM, Chen IS, Hahn WC, Sharp PA, Weinberg RA, Novina CD.

RNA. 2003 Apr;9(4):493-501. doi: 10.1261/rna.2192803.

PMID: 12649500

Applications of transfected cell microarrays in high-throughput drug discovery.

Bailey SN, Wu RZ, Sabatini DM.

Drug Discov Today. 2002 Sep 15;7(18 Suppl):S113-8. doi: 10.1016/s1359-6446(02)02386-3.

PMID: 12546876

Cell-biological applications of transfected-cell microarrays.

Wu RZ, Bailey SN, Sabatini DM.

Trends Cell Biol. 2002 Oct;12(10):485-8. doi: 10.1016/s0962-8924(02)02354-1.

PMID: 12441253

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery.

Kim DH, Sarbassov DD, Ali SM, King JE, Latek RR, Erdjument-Bromage H, Tempst P, Sabatini DM.

Cell. 2002 Jul 26;110(2):163-75. doi: 10.1016/s0092-8674(02)00808-5.

PMID: 12150925

The immunosuppressant rapamycin mimics a starvation-like signal distinct from amino acid and glucose deprivation.

Peng T, Golub TR, Sabatini DM.

Mol Cell Biol. 2002 Aug;22(15):5575-84. doi: 10.1128/MCB.22.15.5575-5584.2002.

PMID: 12101249

Enumeration of the simian virus 40 early region elements necessary for human cell transformation.

Hahn WC, Dessain SK, Brooks MW, King JE, Elenbaas B, Sabatini DM, DeCaprio JA, Weinberg RA.

Mol Cell Biol. 2002 Apr;22(7):2111-23. doi: 10.1128/MCB.22.7.2111-2123.2002.

PMID: 11884599

Microarrays of cells expressing defined cDNAs.

Ziauddin J, Sabatini DM.

Nature. 2001 May 3;411(6833):107-10. doi: 10.1038/35075114.

PMID: 11333987

Interaction of RAFT1 with gephyrin required for rapamycin-sensitive signaling.

Sabatini DM, Barrow RK, Blackshaw S, Burnett PE, Lai MM, Field ME, Bahr BA, Kirsch J, Betz H, Snyder SH.

Science. 1999 May 14;284(5417):1161-4. doi: 10.1126/science.284.5417.1161.

PMID: 10325225

The 12 kD FK 506 binding protein FKBP12 is released in the male reproductive tract and stimulates sperm motility.

Walensky LD, Dawson TM, Steiner JP, Sabatini DM, Suarez JD, Klinefelter GR, Snyder SH.

Mol Med. 1998 Aug;4(8):502-14.

PMID: 9742506

Neurabin is a synaptic protein linking p70 S6 kinase and the neuronal cytoskeleton.

Burnett PE, Blackshaw S, Lai MM, Qureshi IA, Burnett AF, Sabatini DM, Snyder SH.

Proc Natl Acad Sci U S A. 1998 Jul 7;95(14):8351-6. doi: 10.1073/pnas.95.14.8351.

PMID: 9653190

Neural actions of immunophilin ligands.

Snyder SH, Sabatini DM, Lai MM, Steiner JP, Hamilton GS, Suzdak PD.

Trends Pharmacol Sci. 1998 Jan;19(1):21-6. doi: 10.1016/s0165-6147(97)01146-2.

PMID: 9509898

RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1.

Burnett PE, Barrow RK, Cohen NA, Snyder SH, Sabatini DM.

Proc Natl Acad Sci U S A. 1998 Feb 17;95(4):1432-7. doi: 10.1073/pnas.95.4.1432.

PMID: 9465032

Neural roles of immunophilins and their ligands.

Sabatini DM, Lai MM, Snyder SH.

Mol Neurobiol. 1997 Oct;15(2):223-39. doi: 10.1007/BF02740635.

PMID: 9396011

Lymphocyte apoptosis: mediation by increased type 3 inositol 1,4,5-trisphosphate receptor.

Khan AA, Soloski MJ, Sharp AH, Schilling G, Sabatini DM, Li SH, Ross CA, Snyder SH.

Science. 1996 Jul 26;273(5274):503-7. doi: 10.1126/science.273.5274.503.

PMID: 8662540.

The rapamycin and FKBP12 target (RAFT) displays phosphatidylinositol 4-kinase activity.

Sabatini DM, Pierchala BA, Barrow RK, Schell MJ, Snyder SH.

J Biol Chem. 1995 Sep 8;270(36):20875-8. doi: 10.1074/jbc.270.36.20875.

PMID: 7673106

Immunophilin FK506 binding protein associated with inositol 1,4,5-trisphosphate receptor modulates calcium flux.

Cameron AM, Steiner JP, Sabatini DM, Kaplin AI, Walensky LD, Snyder SH.

Proc Natl Acad Sci U S A. 1995 Feb 28;92(5):1784-8. doi: 10.1073/pnas.92.5.1784.

PMID: 7533300

Immunophilins and the nervous system.

Snyder SH, Sabatini DM.

Nat Med. 1995 Jan;1(1):32-7. doi: 10.1038/nm0195-32.

PMID: 7584950

High-sensitivity sequencing of large proteins: partial structure of the rapamycin-FKBP12 target.

Erdjument-Bromage H, Lui M, Sabatini DM, Snyder SH, Tempst P.

Protein Sci. 1994 Dec;3(12):2435-46. doi: 10.1002/pro.5560031227.

PMID: 7756997

RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs.

Sabatini DM, Erdjument-Bromage H, Lui M, Tempst P, Snyder SH.

Cell. 1994 Jul 15;78(1):35-43. doi: 10.1016/0092-8674(94)90570-3.

PMID: 7518356

Colony stimulating factor-1 (CSF-1) stimulates temperature dependent phosphorylation and activation of the RAF-1 proto-oncogene product.

Baccarini M, Sabatini DM, App H, Rapp UR, Stanley ER.

EMBO J. 1990 Nov;9(11):3649-57. doi: 10.1002/j.1460-2075.1990.tb07576.x.

PMID: 1698619

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